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Visit El Draque's column >>

EL DRAQUE

Articles Posted: 24  Links Seeded: 495
Member Since: 2/2006  Last Seen: 3/17/2012

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Scientists discover the secret of ageing

Seeded on Tue Feb 16, 2010 12:58 PM EST
Read ArticleArticle Source: FT.com
health, biology, dna, age, cells, ageing, old-people, telomeres
Seeded by El Draque
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One of the biggest puzzles in biology – how and why living cells age – has been solved by an international team based at Newcastle University, in north-east England.

The answer is complex, and will not produce an elixir of eternal life in the foreseeable future.

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  • Public Discussion (4)
El Draque

This is something that is ongoing. I have also heard people speculate about nuclear pores becoming deficient with age as well. This is pretty interesting stuff.

  • 2 votes
Reply#1 - Tue Feb 16, 2010 1:00 PM EST
JoulesBeef

did you used to have a different nick here?
just asking.

cool article

    #1.1 - Tue Feb 16, 2010 1:42 PM EST
    GOZO-unlimited

    These Substances may Protect the Body’s Endogenous DNA

    Alkaloids

    The Trimethylglycine (TMG) form of Betaine may help to protect the body’s cellular DNA from damage (by functioning as a methyl donor). references

    Amino Acids

    Acetyl-L-Carnitine may inhibit and reverse damage to mitochondrial DNA (mtDNA). references
    N-Acetyl-Cysteine may protect the body’s DNA from damage: references

    - NAC may prevent the Cross-Linking of the body’s endogenous DNA that is caused by Tobacco Smoking.

    Auxins

    Indole-3-Carbinol may reduce the ability of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to damage the body’s endogenous DNA. references

    Carotenoids

    Beta-Carotene may protect DNA from oxidative damage. references
    Lutein may protect DNA from oxidative damage. references
    Lycopene may protect the DNA content of Lymphocytes and Liver cells from oxidative damage. references

    Coenzymes

    Coenzyme A may facilitate the repair of the body’s endogenous DNA.
    NADH may facilitate the repair of damaged DNA (presumably by supplying the Energy necessary to “fuel” the repair of DNA). references

    Enzymes

    Sir2p protects DNA from the “Cell strangulation” and “cellular death” messages issued by Extrachromasomal rDNA Circles (ERCs). references

    Hormones

    Melatonin may prevent Free Radicals from damaging (fragmenting) the DNA content of Cells: references

    - Melatonin prevents Amyloid-Beta Protein (the Neurotoxin that is strongly implicated in Alzheimer’s Disease) from causing oxidative damage to the (mitochondrial) DNA of the Mitochondria of Cells.

    Minerals

    Zinc may help to repair damaged DNA. references

    Peptides

    Glutathione activates enzymes that repair damaged DNA. references

    Phenolic Acids

    Ellagic Acid may form adducts with the body’s endogenous DNA, thereby blocking binding sites on the DNA of Cells that could otherwise be occupied by carcinogens or mutagens. references
    Ferulic Acid may help to prevent damage to the body’s DNA. references

    Polyphenols

    Apigenin may help to prevent oxidative damage to the body’s endogenous DNA. references
    Epigallo-Catechin-Gallate (EGCG) may protect the body’s endogenous DNA from damage (including the damage inflicted by exposure to Ultra-Violet Radiation). references
    Luteolin may help to prevent oxidative damage to the body’s endogenous DNA. references

    Oligomeric Proanthocyanidins (OPCs) may help to prevent damage to the DNA content of Cells. references
    Pycnogenol may help to prevent damage to the DNA content of Cells (due to the OPC content of Pycnogenol). references
    Quercetin may protect the body’s endogenous DNA from breakage and oxidation (by chelating (removing) Ferric Iron from the body). Quercetin may inhibit the damage to the body’s DNA caused by Benzpyrene. references

    Rutin may help to prevent oxidative damage to the body’s endogenous DNA. references

    Quinones

    Coenzyme Q10 may protect the body’s endogenous DNA (including Mitochondrial DNA) from oxidative damage caused by Free Radicals (via its Antioxidant properties). references

    Smart Drugs

    Idebenone may protect mitochondrial DNA (mtDNA) from the damage caused by Free Radicals (due to the Antioxidant effects of Idebenone). references

    Vitamins

    Choline may help to prevent damage to the body’s endogenus DNA. references
    Folic Acid may help to repair damaged DNA. references
    Inositol Hexaphosphate may facilitate the repair of damaged DNA (it repairs double-strand DNA breaks). references

    Lipoic Acid may inhibit damage to mitochondrial DNA (mtDNA). references
    Vitamin B3 (especially the Niacinamide form of Vitamin B3) may help to repair damaged DNA. references
    Vitamin C may facilitate the repair of damaged endogenous DNA. references

    - Vitamin C may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA).

    Vitamin E may prevent Free Radical damage to DNA: references

    - Vitamin E may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA).
    - Tocotrienols may help to prevent damage to the body’s endogenous Deoxyribonucleic Acid (DNA). references

    These Foods/Herbs may Protect the Body’s Endogenous DNA

    Algae

    Spirulina may facilitate the repair of damaged DNA in Cells (due to Polysaccharides in Spirulina). references

    Fruit

    Grapes may inhibit damage to the body’s DNA. references

    Grasses

    Barley Grass may protect the body’s endogenous DNA during the meiotic division phase of Cell division. references

    Herbs

    Cat’s Claw may help to prevent damage to the body’s endogenous DNA and facilitates the repair of damaged DNA. references
    Ginkgo biloba may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA). references
    Golden Root may facilitate the repair of damaged DNA and may help to protect DNA from damage. references

    Green Tea may protect human DNA from the formation of adducts (lesions). references
    Korean Ginseng may inhibit the oxidative damage caused to the body’s endogenous DNA caused by the Free Radicals generated by Tobacco smoking. references
    Skullcap may help to repair damaged DNA (due to the Baicalein content of Skullcap). references

    Seeds

    Grape Seeds may help to prevent damage to the DNA content of Cells (due to the OPCs content of Grape Seeds). references

    Vegetables

    Watercress may help to prevent damage to the body’s endogenous Deoxyribonucleic Acid (DNA). references

    Other Factors that Protect Endogenous DNA

    Diets

    Diet Restriction may improve the efficiency of the endogenous repair of damaged DNA. [more info]

    Dietary Sources of DNA note

    Bee Foods: Bee Pollen
    Seafood: Anchovy
    Yeasts: Brewer's Yeast

    In-Tele-Health

    If your interested in references....let me know.

    • 2 votes
    #1.2 - Tue Feb 16, 2010 10:09 PM EST
    El Draque

    No Joules, this is the same nick name that has been here since 2006. Since then I have been engaged in a Science program at school that is dealing with some of these issues so I have a lot more interest in them as well as much more knowledge than I used to.

    Indeed, GOZO, some of that seems interesting.

    • 1 vote
    #1.3 - Tue Feb 16, 2010 10:39 PM EST
    Reply
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