One of the biggest puzzles in biology – how and why living cells age – has been solved by an international team based at Newcastle University, in north-east England.
The answer is complex, and will not produce an elixir of eternal life in the foreseeable future.
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- Public Discussion (4)
This is something that is ongoing. I have also heard people speculate about nuclear pores becoming deficient with age as well. This is pretty interesting stuff.
- 2 votes
did you used to have a different nick here?
just asking.
cool article
These Substances may Protect the Body’s Endogenous DNA
Alkaloids
The Trimethylglycine (TMG) form of Betaine may help to protect the body’s cellular DNA from damage (by functioning as a methyl donor). references
Amino Acids
Acetyl-L-Carnitine may inhibit and reverse damage to mitochondrial DNA (mtDNA). references
N-Acetyl-Cysteine may protect the body’s DNA from damage: references
- NAC may prevent the Cross-Linking of the body’s endogenous DNA that is caused by Tobacco Smoking.
Auxins
Indole-3-Carbinol may reduce the ability of Heterocyclic Aromatic Amines (HAAs) (e.g. PhlP) to damage the body’s endogenous DNA. references
Carotenoids
Beta-Carotene may protect DNA from oxidative damage. references
Lutein may protect DNA from oxidative damage. references
Lycopene may protect the DNA content of Lymphocytes and Liver cells from oxidative damage. references
Coenzymes
Coenzyme A may facilitate the repair of the body’s endogenous DNA.
NADH may facilitate the repair of damaged DNA (presumably by supplying the Energy necessary to “fuel” the repair of DNA). references
Enzymes
Sir2p protects DNA from the “Cell strangulation” and “cellular death” messages issued by Extrachromasomal rDNA Circles (ERCs). references
Hormones
Melatonin may prevent Free Radicals from damaging (fragmenting) the DNA content of Cells: references
- Melatonin prevents Amyloid-Beta Protein (the Neurotoxin that is strongly implicated in Alzheimer’s Disease) from causing oxidative damage to the (mitochondrial) DNA of the Mitochondria of Cells.
Minerals
Zinc may help to repair damaged DNA. references
Peptides
Glutathione activates enzymes that repair damaged DNA. references
Phenolic Acids
Ellagic Acid may form adducts with the body’s endogenous DNA, thereby blocking binding sites on the DNA of Cells that could otherwise be occupied by carcinogens or mutagens. references
Ferulic Acid may help to prevent damage to the body’s DNA. references
Polyphenols
Apigenin may help to prevent oxidative damage to the body’s endogenous DNA. references
Epigallo-Catechin-Gallate (EGCG) may protect the body’s endogenous DNA from damage (including the damage inflicted by exposure to Ultra-Violet Radiation). references
Luteolin may help to prevent oxidative damage to the body’s endogenous DNA. references
Oligomeric Proanthocyanidins (OPCs) may help to prevent damage to the DNA content of Cells. references
Pycnogenol may help to prevent damage to the DNA content of Cells (due to the OPC content of Pycnogenol). references
Quercetin may protect the body’s endogenous DNA from breakage and oxidation (by chelating (removing) Ferric Iron from the body). Quercetin may inhibit the damage to the body’s DNA caused by Benzpyrene. references
Rutin may help to prevent oxidative damage to the body’s endogenous DNA. references
Quinones
Coenzyme Q10 may protect the body’s endogenous DNA (including Mitochondrial DNA) from oxidative damage caused by Free Radicals (via its Antioxidant properties). references
Smart Drugs
Idebenone may protect mitochondrial DNA (mtDNA) from the damage caused by Free Radicals (due to the Antioxidant effects of Idebenone). references
Vitamins
Choline may help to prevent damage to the body’s endogenus DNA. references
Folic Acid may help to repair damaged DNA. references
Inositol Hexaphosphate may facilitate the repair of damaged DNA (it repairs double-strand DNA breaks). references
Lipoic Acid may inhibit damage to mitochondrial DNA (mtDNA). references
Vitamin B3 (especially the Niacinamide form of Vitamin B3) may help to repair damaged DNA. references
Vitamin C may facilitate the repair of damaged endogenous DNA. references
- Vitamin C may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA).
Vitamin E may prevent Free Radical damage to DNA: references
- Vitamin E may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA).
- Tocotrienols may help to prevent damage to the body’s endogenous Deoxyribonucleic Acid (DNA). references
These Foods/Herbs may Protect the Body’s Endogenous DNA
Algae
Spirulina may facilitate the repair of damaged DNA in Cells (due to Polysaccharides in Spirulina). references
Fruit
Grapes may inhibit damage to the body’s DNA. references
Grasses
Barley Grass may protect the body’s endogenous DNA during the meiotic division phase of Cell division. references
Herbs
Cat’s Claw may help to prevent damage to the body’s endogenous DNA and facilitates the repair of damaged DNA. references
Ginkgo biloba may protect against age-associated oxidative damage to Mitochondrial DNA (mtDNA). references
Golden Root may facilitate the repair of damaged DNA and may help to protect DNA from damage. references
Green Tea may protect human DNA from the formation of adducts (lesions). references
Korean Ginseng may inhibit the oxidative damage caused to the body’s endogenous DNA caused by the Free Radicals generated by Tobacco smoking. references
Skullcap may help to repair damaged DNA (due to the Baicalein content of Skullcap). references
Seeds
Grape Seeds may help to prevent damage to the DNA content of Cells (due to the OPCs content of Grape Seeds). references
Vegetables
Watercress may help to prevent damage to the body’s endogenous Deoxyribonucleic Acid (DNA). references
Other Factors that Protect Endogenous DNA
Diets
Diet Restriction may improve the efficiency of the endogenous repair of damaged DNA. [more info]
Dietary Sources of DNA note
Bee Foods: Bee Pollen
Seafood: Anchovy
Yeasts: Brewer's Yeast
In-Tele-Health
If your interested in references....let me know.
- 2 votes
No Joules, this is the same nick name that has been here since 2006. Since then I have been engaged in a Science program at school that is dealing with some of these issues so I have a lot more interest in them as well as much more knowledge than I used to.
Indeed, GOZO, some of that seems interesting.
- 1 vote
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